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KMID : 1123920140280040379
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Korean Journal of Oriental Physiology and Pathology
2014 Volume.28 No. 4 p.379 ~ p.383
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Effect of Ethanolic Extract of Silkworm on Reactive Oxygen Species Formation in vivo
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Kang Young-Kook
Choi Min-Joo
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Abstract
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The purpose of this study is to investigate the effects of silkworm extracts (SWE) on reactive oxygen species
formation in mice (C57BL/6). Mice were administrated intraperitoneally with SWE (20 mg/kg/day) for 14 days. All
animals were sacrificed 24 hours after the last SWE treatment and then extracted the blood and brain tissue in mouse.
The researcher measured several parameters related to reactive oxygen species formation, malondialdehyde (MDA)
and hydrogen peroxide (H2O2) contents in serum, whole brain, cerebral cortex and cerebellum. The results showed that
MDA content of pre-SWE treatment was decreased significantly in serum, mitochondrial and cytosolic fraction of whole
brain and cerebellum (P<0.01). The H2O2 content of pre-SWE treatment was decreased significantly in mitochondrial
fraction of whole brain, cerebral cortex and cerebellum (P<0.01). These results suggest that SWE plays an important
role for inhibition of oxidative damage of cells as well as antioxidant effect, aging delay and cells protected from
irradiation. ???????????
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KEYWORD
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H2O2, silkworm, oxidative damage, antioxidant, MDA
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